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Elaboration and profiling of the first OSBP degrader issued from natural Schweinfurthins

Carole Guimard et al.
HAL (France) · Papers
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We describe the two-step synthesis and in vitro validation of the first oxysterol-binding protein (OSBP) PROTAC deriving from a natural schweinfurthin (SW). SWs, like other families of natural molecules that target OSBP, have a specific cytotoxic profile r
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