PPARγ-dependent and -independent regulation of genes involved in hepatic methionine cycle in fasted or diet-induced obese mice

Metabolic dysfunction-associated steatohepatitis (MASH) is associated with increased expression of hepatocyte peroxisome proliferator-activated receptor gamma (PPARγ, Pparg) and reduced expression of hepatic genes involved in the methionine cycle. The nuclear receptor PPARγ is activated by fatty ac