PLOS
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CC BY 4.0
Collagen I promotes cancer cell survival via amino acid import and mTORC1/S6 activation
Invasive breast and pancreatic cancer cells thrive within a collagen I-rich, poorly perfused extracellular matrix (ECM) network, necessitating robust metabolic adaptation to endure nutrient deficiency, such as glucose starvation. Here we demonstrate that collagen I is critical for the survival and
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