In vivo and in vitro assessment of absorption and disposition kinetics of bis[2-(perfluorohexyl)ethyl] phosphate in rats: food effect, physiologically-based modeling, and human exposure estimation

Bis[2-(perfluorohexyl)ethyl] phosphate (6:2 diPAP) is a widely used per- and poly-fluoroalkyl substance of toxicological concern considering its environmental persistence and potential for human exposure. To establish a mechanistic basis for evaluating internal exposure, this study experimentally ch