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The cytotoxic domain of colicin E9 is a channel-forming endonuclease

Mosbahi, Khédidja et al.
White Rose Research Online · Papers
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uk
Bacterial toxins commonly translocate cytotoxic enzymes into cells using dedicated channelforming subunits or domains as conduits. We demonstrate that the small cytotoxic endonuclease domain from the bacterial toxin colicin E9 (the E9 DNase) exhibits nonvoltage- gated, channel-forming activity in pl
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