Mitotic lineage adds predictive information beyond cell type in the C. elegans connectome

Mitotic lineage adds predictive information beyond cell type in the C. elegans connectome | bioRxiv Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search New Results Mitotic lineage adds predictive information beyond cell type in the C. elegans connectome View ORCID Profile Jordan K. Matelsky , View ORCID Profile Brock Wester , View ORCID Profile Konrad P. Körding doi: https://doi.org/10.1101/2022.11.01.514680 Jordan K. Matelsky a Johns Hopkins Applied Physics Laboratory , Laurel, Maryland, United States b Department of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania, United States Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Jordan K. Matelsky For correspondence: matelsky{at}upenn.edu Brock Wester a Johns Hopkins Applied Physics Laboratory , Laurel, Maryland, United States Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Brock Wester Konrad P. Körding b Department of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania, United States c Department of Neuroscience, University of Pennsylvania , Philadelphia, Pennsylvania, United States d CIFAR, LMB program Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Konrad P. Körding Abstract Full Text Info/History Metrics Data/Code Preview PDF Abstract During nervous system development, repeated cell divisions of the zygote give rise to a “family tree” of neurons related by mitotic lineage. The developmental process also gives rise to neuronal connections, and neurons phenotypically converge to different cell types. Neural connections are steered by cell type, but they may be driven in part by lineage: We do not know if lineage matters for the developmental neurogenesis process. We thus asked if mitotic lineage predicts neural connections beyond cell type alone. Using three C. elegans datasets, we fit models for edge prediction tasks: predicting synaptic targets, and predicting synaptic sources. Adding the mitotic lineage improved these predictions. Our results suggest that the family tree matters for the connections made by neurons, and that developmental lineage is a variable that should be considered more deeply in models of connectome assembly. Competing Interest Statement The authors have declared no competing interest. Footnotes Analyses and findings updated, improved treatment of separate adult connectomes. https://github.com/KordingLab/LineageConnectomics Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Back to top Previous Next Posted April 01, 2026. Download PDF Data/Code Email Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Mitotic lineage adds predictive information beyond cell type in the C. elegans connectome Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Share Mitotic lineage adds predictive information beyond cell type in the C. elegans connectome Jordan K. Matelsky , Brock Wester , Konrad P. Körding bioRxiv 2022.11.01.514680; doi: https://doi.org/10.1101/2022.11.01.514680 Share This Article: Copy Citation Tools Mitotic lineage adds predictive information beyond cell type in the C. elegans connectome Jordan K. Matelsky , Brock Wester , Konrad P. Körding bioRxiv 2022.11.01.514680; doi: https://doi.org/10.1101/2022.11.01.514680 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Area Neuroscience Subject Areas All Articles Animal Behavior and Cognition (7999) Biochemistry (18706) Bioengineering (14825) Bioinformatics (44339) Biophysics (22551) Cancer Biology (19666) Cell Biology (26834) Clinical Trials (138) Developmental Biology (13930) Ecology (20965) Epidemiology (2067) Evolutionary Biology (25407) Genetics (16144) Genomics (23464) Immunology (18668) Microbiology (42393) Molecular Biology (18017) Neuroscience (93296) Paleontology (699) Pathology (2976) Pharmacology and Toxicology (5083) Physiology (8102) Plant Biology (15964) Scientific Communication and Education (2094) Synthetic Biology (4549) Systems Biology (10214) Zoology (2382)

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