Expression profiling of the learning striatum

Expression profiling of the learning striatum | bioRxiv Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search New Results Expression profiling of the learning striatum E Lousada , Z Kliesmete , A Janjic , D Richter , LE Wange , E Briem , View ORCID Profile I Hellmann , View ORCID Profile E Burguière , View ORCID Profile W Enard , View ORCID Profile C Schreiweis doi: https://doi.org/10.1101/2023.01.03.522560 E Lousada 1 Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM , Inserm, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France Find this author on Google Scholar Find this author on PubMed Search for this author on this site Z Kliesmete 2 Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität München , Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site A Janjic 2 Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität München , Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site D Richter 2 Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität München , Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site LE Wange 2 Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität München , Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site E Briem 2 Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität München , Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site I Hellmann 2 Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität München , Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for I Hellmann E Burguière 1 Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM , Inserm, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France 3 CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028, UMR5292, Team Neurophysiology of Repetitive Behaviours, Université Claude Bernard Lyon 1, Centre Hospitalier Le Vinatier , Bron, France Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for E Burguière W Enard 2 Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität München , Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for W Enard For correspondence: christiane.schreiweis{at}univ-lyon1.fr enard{at}bio.lmu.de C Schreiweis 1 Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM , Inserm, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France 3 CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028, UMR5292, Team Neurophysiology of Repetitive Behaviours, Université Claude Bernard Lyon 1, Centre Hospitalier Le Vinatier , Bron, France 4 Université Claude Bernard Lyon 1 (UCBL) , 69622 Villeurbanne Cedex, France Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for C Schreiweis For correspondence: christiane.schreiweis{at}univ-lyon1.fr enard{at}bio.lmu.de Abstract Full Text Info/History Metrics Supplementary material Preview PDF Abstract How learning reshapes the brain across temporal and spatial scales, from molecular to cellular levels, remains a fundamental question in neuroscience. In the striatum, ventromedial, dorsomedial and dorsolateral subregions are differentially recruited during early to late learning on a neurophysiological level. Here, we profile the transcriptome of these subregions across 396 biopsies from 66 mice to map molecular dynamics at three learning stages of a visual discrimination task. We find a strong transcriptional change during the early phase that diminishes towards later learning and is indistinguishable among subregions. The 818 genes altered during learning are enriched for neuronal processes, but also include circadian, vascular, and oligodendrocyte-related pathways. We provide a web application for this large learning-related expression dataset, enabling interactive exploration of genes, gene sets, and transcription factor activity, and suggest that this framework will be broadly useful for diverse neuroscience questions. Competing Interest Statement The authors have declared no competing interest. Footnotes Version 2 of the manuscript includes: - new analyses and results - used-friendly web application for exploration of gene expression data - completely revised manuscript text Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Back to top Previous Next Posted April 12, 2026. Download PDF Supplementary Material Email Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Expression profiling of the learning striatum Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website. 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Share Expression profiling of the learning striatum E Lousada , Z Kliesmete , A Janjic , D Richter , LE Wange , E Briem , I Hellmann , E Burguière , W Enard , C Schreiweis bioRxiv 2023.01.03.522560; doi: https://doi.org/10.1101/2023.01.03.522560 Share This Article: Copy Citation Tools Expression profiling of the learning striatum E Lousada , Z Kliesmete , A Janjic , D Richter , LE Wange , E Briem , I Hellmann , E Burguière , W Enard , C Schreiweis bioRxiv 2023.01.03.522560; doi: https://doi.org/10.1101/2023.01.03.522560 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Area Neuroscience Subject Areas All Articles Animal Behavior and Cognition (7999) Biochemistry (18706) Bioengineering (14824) Bioinformatics (44334) Biophysics (22548) Cancer Biology (19666) Cell Biology (26832) Clinical Trials (138) Developmental Biology (13930) Ecology (20965) Epidemiology (2067) Evolutionary Biology (25405) Genetics (16143) Genomics (23460) Immunology (18665) Microbiology (42391) Molecular Biology (18015) Neuroscience (93287) Paleontology (699) Pathology (2976) Pharmacology and Toxicology (5083) Physiology (8100) Plant Biology (15963) Scientific Communication and Education (2094) Synthetic Biology (4548) Systems Biology (10214) Zoology (2382)

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