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Peroxisome proliferator activator receptor gamma coactivator-1α overexpression in amyotrophic lateral sclerosis: A tale of two transgenics
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder manifesting with upper and lower neuron loss, leading to impairments in voluntary muscle function and atrophy. Mitochondrial dysfunction in metabolism and morphology have been implicated in the pathogenesis of ALS, inclu
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