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Global trends in proteome remodeling of the outer membrane modulate antimicrobial permeability in Klebsiella pneumoniae
In Gram-negative bacteria, the permeability of the outer membrane governs rates of antibiotic uptake and thus the efficacy of antimicrobial treatment. Hydrophilic drugs like β-lactam antibiotics depend on diffusion through pore-forming outer membrane proteins to reach their intracellular targets. In
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