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A Pharmacokinetic Study of L-697,661 Alone and in Combination With Zidovudine
acquired-immunodeficiency-syndromeantiviral-agentscombinationdrug-therapydrugshiv-infectionsinvestigational
Part 1: To study the potential safety and pharmacokinetic (blood level) effects of zidovudine (AZT) on L-697,661; to obtain additional pharmacokinetic information in humans with L-697,661; to study the effect of L-697,661 on hepatic enzyme induction. Part 2: To begin a study of the antiviral activity of L-697,661. L-697,661 is a newly identified compound that inhibits HIV replication (reproduction and growth) in cell culture. It works together with AZT against HIV.
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