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Troponin I Level and Mortality in Acute Abdominal Surgery

Nordsjaellands Hospital · 2019
ClinicalTrials.gov · Datasets · License: Public Domain · 2019
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The goal of this prospective cohort study is to estimate the incidence of myocardial injury after non-cardiac surgery (MINS) in patients undergoing acute high-risk abdominal surgery. MINS is defined as at least one increased single measurement of plasma troponin I (TnI). TnI-dynamic is defined as either two succeeding measurements of TnI \> 59 ng/l with an increase/fall of more than 20%, or by one measurements of TnI \> 59 ng/l with a succeeding measurement of TnI \< 59 ng/l and a decrease of more than 50%. Participants will have plasma TnI measured 6-12 hours postoperatively and on each of the following four postoperative days. Follow-up will be minimum one year after surgery. The aim of the study is to determine: * The incidence of MINS within the first four postoperative days * The incidence of dynamic TnI changes * The association between MINS and dynamic TnI changes respectively and all-course short-term mortality
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