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Antibody Hotspot-Centric de Novo Design of Peptide Inhibitors of Influenza A Virus Membrane Fusion
Here we report the applicability of a hotspot-centric approach for de novo computational design of l-peptides based on crystal structures of antigen–antibody complexes. Broadly neutralizing antibodies (bnAbs) FI6v3 and CR9114, which target influenza A virus hemagglutinin (HA), guided the pept
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