The stereoselective synthesis of a novel aromatic peptide nucleic acid (APNA) oligomer

The synthesis of the thymine derivative (S)-50, was achieved in high enantiomeric purity (98% ee). The (R) enhanced enantiomer was also synthesized with moderate enantiomeric purity (46% ee). This acyclic pyrimidine analog ((S)-50) is a useful building block for the synthesis of a novel class of oli