bioRxiv / medRxiv
open access
CC BY 4.0
IgA1 hinge-region O-glycoform signatures associated with disease phase and kidney involvement in pediatric IgA vasculitis: a cross-sectional mass-spectrometry study
BackgroundIgA vasculitis (IgAV) is the most common systemic vasculitis in children, and its prognosis is largely determined by renal involvement (IgAV nephritis). No routine blood test identifies IgAV or stratifies the risk of nephritis, although aberrant O-glycosylation of the IgA1 hinge region is
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