bioRxiv / medRxiv
open access
CC BY 4.0
The VPS35 p.A320V variant segregates with Parkinson's disease in a pesticide-exposed family
BackgroundThe VPS35 p.D620N variant causes autosomal dominant Parkinsons disease (PD) and has been shown to activate the LRRK2 kinase pathway, resulting in increased Rab substrate phosphorylation in peripheral immune cells and elevated urinary bis(monoacylglycero)phosphate (BMP) levels. Recently, a
Conceptio Open Archive
Analyze & explore related research in Conceptio
Connect this record directly into your research workflow or AI agent. Explore citations across open repositories, query full text, and export structured proof bundles.
This document is indexed with metadata only: full text is not available in the archive for this record. Open the official source ↗
Related documents
- A systematic genomic screen of 755 early-onset Parkinson’s patients from the 100,000 Genomes Project increases diagnostic yield and directs clinical pathways#29691
- A Study of MK0657 in Parkinson's Disease Patients (0657-006)#995421
- An N-acylphosphatidylethanolamine-LRRK2 axis controls lysosomal homeostasis in Parkinson s disease#329313
- An Extension Study to Assess the Safety, Tolerability and Efficacy of ABT-SLV187 in Subjects With Advanced Parkinson's Disease and Persistent Motor-Complications Despite Optimized Treatment With Available Anti-Parkinsonian Medications#831294
- Qualitative assessment of the clinical meaningfulness of MDS-UPDRS part III items in early-stage Parkinson's.#437233
Record · ID 1043971
Retrieved via Conceptio: every document is proof-bundled with source, license, and retrieval metadata.
Retrieved via Conceptio: every document is proof-bundled with source, license, and retrieval metadata.
Bring this data into your agent: Connect via MCP or API · 20 free credits to start · no card required
Read the Docs → · View CLI source on GitHub · Conceptio Open Knowledge Archive
Read the Docs → · View CLI source on GitHub · Conceptio Open Knowledge Archive