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Synaptic Maturation in Human Induced Neurons Reveals Pathology of Aging and Disease

Agarwal, Ravi Kumar
eScholarship · Papers
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agingcellular-biologyepigeneticsneurodegenerationneuroscienceneurosciencespathology
Fundamentally at the cellular level, Alzheimer's disease is a synaptic disease marked by loss of cortical glutamatergic synaptic density, and no widely used cellular model simultaneously preserves donor age and produces cortical neurons mature enough to interrogate disease-relevant synaptic biology.
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