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Investigating Intracellular Consequences of IDH1 Mutations
Isocitrate dehydrogenase 1 (IDH1) is a homodimeric enzyme that catalyzes the reversible NADP+-dependent oxidation of isocitrate (ICT) to α-ketoglutarate (αKG) in the cytoplasm and peroxisomes. Somatic mutations in IDH1 have been implicated in lower grade gliomas, chondrosarcomas, and intrahepatic ch
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