UBIRA ETheses
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Understanding the regulators of adaptive tolerance in chronically stimulated CD4+ T-cells.
Chronic T-cell receptor (TCR) stimulation is a central driver of CD4+ T-cell hyporesponsiveness. During prolonged stimulation, CD4+ T-cells either enter a state of tolerance, mimicking anergy, or differentiate into type-1 regulatory T-cells (Tr1), a distinct FoxP3- regulatory T-cell (Treg) subset cr
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