In silico approach to the discovery of potential non-hydroxamate LpxC inhibitors against pseudomonas aeruginosa and the synthesis and characterization of the precursor compounds of avocadyne analogs

Part I. Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen and is the second-most critical antibiotic-resistant gram-negative bacteria (GNB). The lipopolysaccharide (LPS) layer on P. aeruginosa’s outer membrane serves as a protective barrier against antimicrobial agents and has an e