Imaging of Advanced Tumours Using [131]I-IAZA

Hypoxic cells in tumors have less oxygen than normal cells do, which leads to several changes inside the cells that lead to genetic chages making these cells resistant to treatment. The end result of this is increased tumor growth, spread of the tumor and poor outcome. Early studies have shown that \[131\]I-IAZA scans can help detect if there are hypoxic cells in the tumor. A \[131\]I-IAZA scan is a nuclear medicine test used to create pictures of the whole body after \[131\]I-IAZA is injected into a vein. Further scientific research will help understand how \[131\]I-IAZA is distributed throughout the body and how it can be used to treat hypoxic tumor cells. The purpose of this study is to : 1. Demonstrate the safety of \[131\]I-IAZA 2. To Determine the biodistribution and tumor avidity of \[131\]I-IAZA in patients with locally advanced or metastatic solid tumors. 3. To determine the optimal imaging time of \[131\]I-IAZA SPECT. 4. To collect data from imaging and plasma sampling for radiopharmacokinetic analysis of \[131\]I-IAZA. 5. To determine whole body dosimetry of \[131\]I-IAZA in selected patients. 6. To evaluate tumor dosimetry of \[131\]I-IAZA in patients with positive uptake. 7. To determine the radiation dose accrued in hypoxic tumors.