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Interactions of HIV Protease Inhibitors and Methadone in HIV-Infected Patients
combinationdose-response-relationshipdrugdrug-therapyhiv-1hiv-infectionsnarcoticssubstance-related-disorders
The purpose of this study is to see if it is safe to combine methadone with two HIV protease inhibitors (PIs), ritonavir (RTV) and saquinavir (SQV), in HIV-infected patients not currently taking PIs. This study will measure the interactions between methadone and the PIs. Methadone is used treat addicts and to treat severe pain. In order to find the safest way to use methadone with PIs, it is important to evaluate how they interact.
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