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Spatially Resolved Nucleated Polymerization: A Free-Boundary Model of Protein Aggregation in Concentrated Solutions
Kinetic models of protein aggregation describe populations by size, not by spatial organization or morphology. We extend Lumry-Eyring nucleated polymerization to a model in which the monomer is a density field and each aggregate is a region bounded by a level set. Growth is a flux condition on the a
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