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Spatial-Molecular Information Analysis Based on Histopathological Geometry: KL-Divergence Decomposition of Cell Distribution and Location-Dependent Expression States in PD-1 Immunohistochemistry
Spatial biology enables molecular expression to be analyzed together with the location of cells in tissue. However, it is often difficult to distinguish whether cells preferentially accumulate near a histopathological boundary from whether their molecular expression states vary with that location. T
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