Springer Nature OA
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CC BY 4.0
Functional deficiency of circadian regulator PER2 enhances breast cancer susceptibility and progression with immunosuppression
Circadian rhythm (CR) governs systemic and tissue physiological homeostasis by regulating sleep-wake cycles, hormone secretion, and metabolism. CR disruption (CRD), such as shift work, has been associated with increased cancer risk, particularly female breast cancer (BC), yet the mechanisms underlyi
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