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A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD

University of Regensburg · 2021
ClinicalTrials.gov · Datasets · License: Public Domain · 2021
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sickle-cell-disease
HSCT is currently the only curative option for SCD but less than 20% of SCD patients have a MD donor available. So far, all curative approaches beyond a MSD HSCT at young age are non-satisfactory. With the lack of a suitable donor for the vast majority of patients, the major question of this trial is, if a haploidentical αß/CD19+ T-cell depleted HSCT can be a valid alternative to a MSD HSCT. The main challenge in non-malignant diseases is to offer a safe and GvHD-free HSCT without rejection.
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