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Validation of Selective HaloTag-RNA Polymerase I Degradation
Within the nucleolus, RNA Polymerase I (Pol I) transcribes ribosomal DNA (rDNA) into nascent 47S pre-ribosomal RNA (pre-rRNA), which is subsequently processed into mature rRNA species that assemble the large and small ribosomal subunits to sustain cellular protein synthesis. Acute Myeloid Leukemia (
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