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The N-degron pathway regulates glucose and insulin homeostasis through the lysosomal degradation of RXRA/RXRα via SQSTM1/p62
Central to the pathogenesis of type 2 diabetes (T2D) is the failure in insulin secretion from pancreatic beta-cells associated with insulin resistance. The nuclear receptor RXRA/RXR alpha (retinoid X receptor alpha) is a transcriptional regulator of insulin secretion and systemic glucose metabolism.
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