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The Sec11 C-terminal short helix promotes productive engagement of internal signal sequences with the signal peptidase complex

Chung, Yeonji et al.
S-Space: Seoul National University · Papers
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codegenemolecular-dynamics
Proteins destined for secretion typically contain N-terminal signal sequences that target nascent chains to the endoplasmic reticulum. Following targeting, these sequences are cleaved by the heterotetrameric signal peptidase complex (SPC). Despite a conserved N-terminal, hydrophobic core, and C-term
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