Koszul cohomology of Čech cohomology modules

Let $R$ be a commutative Noetherian ring, let $\mathbf{x}=x_1,\ldots,x_n$ be an $R$-regular sequence, and let $\mathbf{y}=y_1,\ldots,y_m$ be a sequence of elements of $R$. Put $I=(\mathbf y)$. Let $\mathcal S$ be a Serre subcategory of the category of $R$-modules. We consider the double complex obta