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Prevalence of Alpha-1 Antitrypsin Deficiency in Non-Cirrhotic Liver Cancer

University Hospital, Bordeaux · 2026
ClinicalTrials.gov · Datasets · License: Public Domain · 2026
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prevalence
Patients with Alpha-1 Antitrypsin Deficiency (AATD), a rare genetic disease, have a 20- to 50-fold higher risk of developing primary liver cancer (PLC), such as hepatocellular carcinoma (HCC), in both cirrhotic and non-cirrhotic livers, highlighting AATD as a potential oncogenic factor. Therefore, our aim is to evaluate the association between AATD and HCC in patients with a non-cirrhotic liver and no known predisposition
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