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Toward MRI Tracking of CAR-T Cells: Optimizing Ferumoxytol Labeling by Mechanoporation
CAR T cell immunotherapy shows promise, but a major barrier to translation is the inability to noninvasively track CAR T cell trafficking and treatment response in brain tumors. Labeling T cells with FDA-approved iron oxide nanoparticles, ferumoxytol, enables detection by magnetic resonance imaging
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