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Dynamic Trafficking of Melanocortin 4 Receptor at the Primary Cilium Reflects Energy Homeostasis
Mutations in the melanocortin 4 receptor (MC4R) are the leading cause of monogenic obesity. MC4R is a key player in the leptin melanocortin pathway, which regulates long term energy homeostasis. Mutations in anorexigenic components of this pathway leads to monogenic obesity. However, the method in w
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