Divisors in projective bundles over the projective line whose complement is affine space

Given a smooth projective variety $X$ of dimension $n$ and a closed subscheme $Z \subseteq X$, it is in general a difficult problem to determine whether $X \setminus Z$ is isomorphic to $\mathbf A^n$. In the case where $X$ is a projective bundle over $\mathbf P^1$ and the restriction of every irredu