bioRxiv / medRxiv
open access
CC BY-NC-ND 4.0
Convergent Inhibitory Cortical Circuit Disruption Drives Genetically Distinct Absence Seizures
Childhood absence epilepsy is one of the most common pediatric epilepsies, characterized by brief involuntary lapse in consciousness and generalized spike-wave discharges (SWDs) on EEG. Despite a growing list of causative genes, the core cortical circuit abnormalities driving this highly stereotyped
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