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Expression of the C-type lectin receptor CD205 on B cells mediates HIV-1 binding and trans infection of CD4+ T cells

Gerberick, A. et al.
bioRxiv / medRxiv · Papers · License: CC BY 4.0
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microbiology
Antigen presenting cells (APC) can bind HIV-1 and subsequently trans infect CD4+ T cells. In comparison to direct (cis) infection of CD4+ T cells by free virus, APC-mediated HIV-1 trans infection is significantly more efficient and requires lower virus titers. As such, B cell-mediated HIV-1 trans in
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