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Exploring Mechanisms of Enhanced Effector Functions in IkBd-overexpressing Cells and Early Exhaustion Transcriptional Change in Activated T Cells
T cell exhaustion impedes adoptive transfer cell therapy efficacy. Previous findings in the atypical IkB transcriptional modulator, IkBd, indicated that its overexpression (OE) enhances CD8+ T cell anti-tumor responses. In this study, we demonstrated that IkBd OE tumor infiltrating lymphocytes (TILs
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