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Hijacking of host PCNA by circovirus replication-associated protein to recruit POLD1 drives viral DNA replication and is inhibited by R428
Circoviruses are the smallest known mammalian viruses with a single-stranded circular genome, whose replication capacity is highly dependent on host factors. Although the virus-encoded replication-associated protein (Rep/Rep’) plays a critical role in circovirus DNA replication, it lacks polymerase
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