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A Pilot Study to Assess Optimal Prevention and Outcome Improvement in Young Ischemic Stroke

IRCCS National Neurological Institute "C. Mondino" Foundation · 2025
ClinicalTrials.gov · Datasets · License: Public Domain · 2025
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Purpose The Y-SCOPE study aims to improve the health and recovery of young adults aged 18 to 65 who have experienced an ischemic stroke or a high-risk transient ischemic attack (TIA). By focusing on personalized care and lifestyle changes, the study seeks to reduce the chances of another stroke and promote better long-term health. Background While strokes are often associated with older adults, recent studies have shown an increase in ischemic strokes among younger individuals. Given that younger patients are typically in their working years and have longer life expectancies, a stroke can lead to significant long-term disability and economic challenges. Addressing the unique needs of this population is crucial for effective care and research. Study Design This is an open-label pilot study, meaning both participants and researchers know which treatments are being administered. The study will enroll 36 participants who will be randomly assigned in a 2:1 ratio: Intervention Group (24 participants): Will receive personalized care through a dedicated "Young Stroke Clinic." Control Group (12 participants): Will receive standard post-stroke care. Intervention Details Participants in the intervention group will: * Attend specialized clinic visits focused on young stroke patients. * Receive intensive counseling to manage risk factors such as high blood pressure, cholesterol, and lifestyle habits. * Be provided with a wearable device (Whoop 4.0) to monitor health metrics like heart rate, sleep patterns, and physical activity. Duration The study will last for 12 months, with an 8-month enrollment period and a minimum follow-up of 6 months for each participant. Eligibility Criteria Inclusion: * Ages 18 to 65. * Diagnosed with acute ischemic stroke or high-risk TIA. * Moderate to low cardiovascular health status. * Able to perform daily activities independently or with minimal assistance. Exclusion: * Pregnancy. * Lack of access to a compatible smartphone for device
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