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Gel-Confined Rolling-Circle Amplification Enables Sensitive Single-Cell Proteoform Analysis

Zhao, Luyao et al.
arXiv (All) · Papers
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quantitative-methods
Protein abundance alone does not capture the molecular diversity generated by protein processing and post-translational modification, yet most single-cell protein assays do not resolve these proteoform states. Here, we develop RCAmp-scWB, a post-separation amplification strategy that performs rollin
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