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The p53-Estrogen Receptor Loop in Cancer

Berger, C et al.
eScholarship · Papers
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31-biological-sciences-for-2020
Tumor suppressor p53 maintains genome stability by regulating diverse cellular functions including cell cycle arrest, apoptosis, senescence and metabolic homeostasis. Mutations in the p53 gene occur in almost all human cancers with a frequency of up to 80%. However, it is only 20% in breast cancers,
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