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4β-hydroxycholesterol-to-cholesterol ratio as an endogenous biomarker in human plasma to determine treatment effects of induction and inhibition of CYP3A4 enzyme activity
Stemming from the induction and/or inhibition of their enzymatic activity, the drug-metabolizing cytochrome P4503A (CYP3A) enzymes, specifically the enzyme CYP3A4, are implicated in drug-drug interactions in several therapeutic areas, including antiretroviral treatment. Whereas the inhibition of CYP
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