bioRxiv / medRxiv
open access
Cocaine-Enhanced Enkephalin Gates Plasticity of Distinct Striatal Synapses and Facilitates Cue-Induced Cocaine-Seeking During Abstinence
Background: Cocaine seeking after abstinence is associated with increased ventral pallidum (VP) activity. This increase appears to involve an opioid peptide that suppresses GABA release from D2 receptor-expressing medium spiny neurons (D2-MSNs) to the VP, but its identity is unclear. We previously f
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