bioRxiv / medRxiv
open access
CC BY-NC-ND 4.0
Characterization and pharmacological modulation of Alzheimers disease-associated human microglial states
Microglia are central mediators of Alzheimers disease (AD) pathogenesis, yet the mechanisms driving disease-associated microglial states and their therapeutic modulation remain poorly understood. Here, we integrated single-nucleus transcriptomic datasets across the AD spectrum and identified disease
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