A kinetic model predicts that tau-catalyzed A$β$ nucleation can raise oligomer burden without increasing plaque volume

Tau and amyloid-$β$ (A$β$) deposits co-occur in Alzheimer's disease, and tau fibrils have recently been shown in vitro to catalyze A$β$ primary nucleation in a fold-specific manner. A two-compartment kinetic model is developed here, describing tau aggregation within the neuronal soma and A$β$ aggreg