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BOP2-ENR: a Bayesian optimal phase II design for adaptive enrichment with family-wise error rate control and a bound on joint-claim power
The Bayesian optimal phase II (BOP2) design accommodates simple and complex endpoints but does not address biomarker-guided enrichment or multiplicity control across pooled and subgroup claims. We propose BOP2-ENR, which monitors biomarker-negative (NG) and biomarker-positive (PG) cohorts separately
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