PLOS
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CC BY 4.0
Epithelial interferon-γ responsiveness shapes chemokine induction and clinical outcomes in herpes simplex virus infection
Herpes simplex virus type 2 (HSV-2) infects genital epithelia and causes a wide spectrum of clinical outcomes, ranging from asymptomatic viral shedding to recurrent self-limited genital lesions. Interferon gamma (IFNγ) is critical in tissue-resident T-cell mediated antiviral defense against HSV-2 r
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