bioRxiv / medRxiv
open access
CC BY 4.0
Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation, decomposes the viral core
Covalent inhibitors form strong, essentially irreversible interactions with their targets, offering enhanced structural selectivity within the target cavity and prolonged target engagement even at low doses. Here, we report that ACAi-001, an HIV-1 capsid (CA)-targeting compound identified through in
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