bioRxiv / medRxiv
open access
CC BY-NC-ND 4.0
Multilayered extracellular matrix derived scaffolds direct progenitor cell differentiation in vitro and osteochondral-tissue formation in vivo.
Osteochondral repair requires restoration of zonally organised articular cartilage and subchondral bone, yet translatable implants rarely reproduce this spatial complexity. Here, we developed an off-the-shelf, cell-free multilayer scaffold comprising a superficial 2% (w/v) articular cartilage extrac
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