bioRxiv / medRxiv
open access
CC BY 4.0
High-Throughput Screening Identifies Small-Molecule Inhibitors of the Tau-LRP1 Interaction
The cellular uptake and propagation of tau are central features of tauopathies, including Alzheimers disease, and are mediated by the endocytic receptor low-density lipoprotein receptor-related protein 1 (LRP1). While prior studies have implicated LRP1 in tau binding and internalization, the biochem
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