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Female Autologous Platelet-Rich Plasma (PRP) Co-incubation With Husband's Sperm

Chinese University of Hong Kong · 2025
ClinicalTrials.gov · Datasets · License: Public Domain · 2025
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Hypotheses: We hypothesize that infertility patients undergoing IUI who receive female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm would have higher clinical pregnancy rate. Aims: * To determine if the use of female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm in the IUI will show higher clinical pregnancy rate (CPR). Clinical pregnancy rate as determined by a positive serum beta-hCG test result and at least one gestational sac at 6 weeks gestation * To assess the safety of female PRP co-incubation with husband's sperm in the IUI. Primary outcome: To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing IUI with female PRP co-incubation with husband's sperm group and non-PRP group. Secondary outcomes: * To evaluate the safeness between the female PRP co-incubation with husband's sperm in the IUI group and non-PRP group, including potential infection rate or other complications such as ectopic pregnancy and molar pregnancy * To evaluate the sperm quality between the intervention group and control group Data analysis: Data analysis will be performed using Statistical Packages of Social Sciences for Windows Expected results: The investigators expect that a 50% pregnancy rate increase after the application of female PRP co-incubation with husband's sperm in the IUI
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